Abstract
Periorbital angio-oedema may present as an isolated manifestation of aspirin intolerance and can be very alarming to the patient. This case describes a 38-year-old gentleman with such localized clinical features. Once considered an unusual phenomenon, review of the literature has revealed an increased frequency, possibly as a result of previous poor documentation. Clinical manifestations of nonsteroidal anti-inflammatory drugs (NSAIDs) intolerance, in particular periorbital angio-oedema and its associated symptoms, with proposed aetiology and pathogenesis, are discussed.