References

Locker D, Shapiro D, Liddell A Who is dentally anxious? Concordance between measures of dental anxiety. Community Dent Oral Epidemiol. 1996; 24:346-350
Hill KB, Chadwick B, Freeman R, O'Sullivan I, Murray JJ Adult Dental Health Survey 2009: relationships between dental attendance patterns, oral health behaviour and the current barriers to dental care. Br Dent J. 2013; 214:25-32
López-Muñoz F, Álamo C, García-García P The discovery of chlordiazepoxide and the clinical introduction of benzodiazepines: half a century of anxiolytic drugs. J Anxiety Disord. 2011; 25:554-562
Ashton H Guidelines for the rational use of benzodiazepines. When and what to use. Drugs. 1994; 48:25-40
Nayeem N, Green TP, Martin IL, Barnard EA Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis. J Neurochem. 1994; 62:815-818
Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations. Physiol Rev. 2007; 87:1215-1284
Rudolph U, Crestani F, Benke D Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999; 401:796-800
Connolly CN, Krishek BJ, McDonald BJ, Smart TG, Moss SJ Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors. J Biol Chem. 1996; 271:89-96
Farrar SJ, Whiting PJ, Bonnert TP, McKernan RM Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer. J Biol Chem. 1999; 274:10100-10104
London: BMJ Group and Pharmaceutical Press; 2014
Whitwam JG, Amrein R Pharmacology of flumazenil. Acta Anaesthesiol Scand (Suppl). 1995; 108:3-14
Lourenço-Matharu L, Roberts GJ Effectiveness and acceptability of intravenous sedation in child and adolescent dental patients: report of a case series at King's College Hospital, London. Br Dent J. 2011; 210:567-572
Litchfield NB Complications of intravenous diazepam – adverse psychological reactions. (An assessment of 16,000 cases.). Anesth Prog. 1980; 28:175-183
Dietch JT, Jennings RK Aggressive dyscontrol in patients treated with benzodiazepines. J Clin Psychiat. 1988; 49:184-188
Mancuso CE, Tanzi MG, Gabay M Paradoxical reactions to benzodiazepines: literature review and treatment options. Pharmacotherapy. 2004; 24:1177-1185
Saïas T, Gallarda T Paradoxical aggressive reactions to benzodiazepine use: a review. Encephale. 2008; 34:330-336
Van der Bijl P, Roelofse JA Disinhibitory reactions to benzodiazepines: a review. J Oral Maxillofac Surg. 1991; 49:519-523
Paton C Benzodiazepines and disinhibition: a review. Psychiatrist. 2002; 26:460-462
Fava M Psychopharmacologic treatment of pathologic aggression. Psychiatr Clin North Am. 1997; 20:427-451
Short TG, Forrest P, Galletly DC Paradoxical reactions to benzodiazepines – a genetically determined phenomenon?. Anaesth Intens Care. 1987; 15:330-345
Khan LC, Lustik SJ Treatment of a paradoxical reaction to midazolam with haloperidol. Anesth Analg. 1997; 85:213-215
Rubin JT, Towbin RB, Bartko M, Baskin KM, Cahill AM, Kaye RD Oral and intravenous caffeine for treatment of children with post-sedation paradoxical hyperactivity. Pediatr Radiol. 2004; 34:980-984
Golparvar M, Saghaei M, Sajedi P, Razavi SS Paradoxical reaction following intravenous midazolam premedication in pediatric patients – a randomized controlled trial of ketamine for rapid tranquilization. Pediatr Anesth. 2004; 14:924-930
Cabrera LC, Santana AS, Robaina PE, Palacios MS Paradoxical reaction to midazolam reversed with flumazenil. J Emerg Trauma Shock. 2010; 3
Rodrigo CR Flumazenil reverses paradoxical reaction with midazolam. Anesth Prog. 1991; 38:65-68
Sanders JC Flumazenil reverses a paradoxical reaction to intravenous midazolam in a child with uneventful prior exposure to midazolam. Pediatr Anesth. 2003; 13:369-370
Thurston TA, Williams CG, Foshee SL Reversal of a paradoxical reaction to midazolam with flumazenil. Anesth Analg. 1996; 83

Benzodiazepines: sedation and agitation

From Volume 43, Issue 1, January 2016 | Pages 83-89

Authors

Catherine Gallagher

MB, BDS, FDS FFD, PCME PCSPM

Lecturer/Specialist in Oral Surgery, University Dental School and Hospital, University College Cork, Ireland

Articles by Catherine Gallagher

Abstract

Dental anxiety is common and frequently poses a barrier to necessary dental treatment. The increasing availability of conscious sedation in dental practice has made treatment much more accessible for anxious patients. At present, benzodiazepines are the most commonly used drugs in sedation practice and provide a pleasant experience for most, but not all, patients. An understanding of the mechanism of action of benzodiazepines should inform our practice and deepen our understanding of why and how sedation may fail.

CPD/Clinical Relevance: As an increasing number of dentists provide sedation for their patients an update on benzodiazepines is timely.

Article

Dental anxiety is a common phenomenon and one with which practising clinicians are all too familiar. Research into the prevalence of dental anxiety in various populations has produced estimates ranging from less than 3% to more than 20%.1 The UK Adult Dental Health Survey 2009 reported extreme dental anxiety in 12% of the adult population and found that this was associated with patients accessing dental treatment only when in pain.2 Anxious patients (and their dentists) experience more stress before and during dental appointments and there are patients who do not receive appropriate dental treatment because they avoid dentists altogether. Sedation in the dental surgery has revolutionized the provision of dental treatment for many such patients, making it acceptable and therefore accessible (Figure 1). More than any other group of drugs, benzodiazepines have allowed the development of safe, predictable sedation by operator-sedationists, such as dentists. An appreciation of the mechanism of action of benzodiazepines, their uses and limitations, can only enhance our success as sedationists and deepen our understanding of why and how benzodiazepine sedation may fail.

Register now to continue reading

Thank you for visiting Dental Update and reading some of our resources. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Up to 2 free articles per month
  • New content available