Nicholas Kalavrezos
Consultant in Head and Neck/Reconstructive Surgery, Head and Neck Centre, University College London Hospitals, London, UK
Mouth cancer for clinicians part 14: cancer prevention
Nicholas KalavrezosThe goal of primary prevention is to protect healthy people from developing cancer. Primary prevention is by far the most ideal approach; strategies include education of the public, high-risk...
Mouth cancer for clinicians part 13: life after mouth cancer treatment
Nicholas KalavrezosSurvival rates for mouth and oropharyngeal cancers have risen slightly over the last 20 years. The best outcome for overall 5-year survival rates for treated oral cancers is over 90% for lip cancer....
Mouth cancer for clinicians part 12: cancer treatment (chemotherapy and targeted therapy)
Nicholas KalavrezosChemotherapy is the use of anti-cancer (cytotoxic) drugs to destroy cancer cells. However, these agents also damage other rapidly-dividing cells, especially in epithelia and haematopoietic tissue, and...
Mouth cancer for clinicians part 11: cancer treatment (radiotherapy)
Nicholas KalavrezosRadiotherapy alone is used to treat some types of mouth and oropharyngeal cancers. RT is an extremely effective treatment for oral squamous cell carcinoma (OSCC), sometimes as a primary modality or as...
Mouth cancer for clinicians part 10: cancer treatment (surgery)
Nicholas KalavrezosSurgery and radiation are the only definitive treatment modalities for both early and locally advanced mouth cancer. Surgical resection, wherein the tumour is completely removed with uninvolved...
Mouth cancer for clinicians part 9: the patient and care team
Nicholas KalavrezosCoping with a diagnosis of cancer, both practically and emotionally, is taxing for all concerned. Patients are likely to feel very upset, frightened, confused and out of control. They need support. It...
Mouth cancer for clinicians part 8: referral
Nicholas KalavrezosGenerally speaking, the earlier a cancer is found and treated, the better the outcome is likely to be with lesser adverse treatment sequelae. In general, cancer prognosis decreases with advanced...
Mouth cancer for clinicians part 7: cancer diagnosis and pre-treatment preparation
Nicholas KalavrezosClinical diagnosis of an early cancer can be quite straightforward if the clinician has adequate level of awareness and suspicion, but potentally malignant disorders (PMDs) that are likely to...
Mouth cancer for clinicians part 6: potentially malignant disorders
Nicholas KalavrezosSome mouth cancers are preceded by clinically obvious potentially malignant disorders (PMDs). There is a range of PMDs known but the most important recognized are erythroplakia (erythroplasia),...
Mouth cancer for clinicians part 5: risk factors (other)
Nicholas KalavrezosThe cause of cancer in most people is still unknown but risk depends on a combination of genes, environment and aspects of our lives (Article 1). It is impossible to control some mouth cancer risk...
Mouth cancer for clinicians part 4: risk factors (traditional: alcohol, betel and others)
Nicholas KalavrezosAlcohol is a depressant. A small amount depresses anxiety and inhibitions and can make the user feel sociable and talkative; too much and a hangover may result, and the person may not even remember...
Mouth cancer for clinicians part 3: risk factors (traditional: tobacco)
Nicholas KalavrezosThe cause of cancer in most people is unclear but risk depends on a combination of genes, environment and aspects of living (Figure 2)..
Mouth cancer for clinicians part 2: epidemiology
Nicholas KalavrezosOral and oropharyngeal cancers together are the sixth leading cancer in the world, with a wide geographical variation, although two-thirds of the cases occur in resource-poor countries, such as...
Mouth cancer for clinicians part 1: cancer
Nicholas KalavrezosThe word tumour in Latin means a swelling but a tumour or swelling is not always a cancer. Some tumours may be caused by inflammation, infections, cysts or fluid-filled lesions or be due to new...
10. Surgical management of oral cancer
Nicholas KalavrezosSurgery was the original treatment developed for oral cancer. It is still widely carried out, in order to achieve more than one of the following goals..