References

Hattab FN, Qudeimat MA, al-Rimawi HS Dental discoloration: an overview. J Esthet Dent. 1999; 11:291-310
Tooth discoloration. eMedicine from WebMD. http://www.emedicine.medscape.com/article/1076389-overview (Accessed May 23, 2012)
Watts A, Addy M Tooth discolouration and staining: a review of the literature. Br Dent J. 2001; 190:309-316
Sulieman M An overview of tooth discoloration: extrinsic, intrinsic and internalized stains. Dent Update. 2005; 32:463-471
Kumar A, Kumar V, Singh J, Hooda A, Dutta S Drug-induced discoloration of teeth: an updated review. Clin Pediatr (Phila). 2012; 51:181-185
Nordbö H, Eriksen HM, Rölla G, Attramadal A, Solheim H Iron staining of the acquired enamel pellicle after exposure to tannic acid or chlorhexidine: preliminary report. Scand J Dent Res. 1982; 90:117-123
Waerhaug M, Gjermo P, Rølla G, Johansen JR Comparison of the effect of chlorhexidine and CuSO4 on plaque formation and development of gingivitis. J Clin Periodontol. 1984; 11:176-180
Vogel RI Intrinsic and extrinsic discoloration of the dentition. J Oral Med. 1975; 30:99-104
West NX, Addy M, Newcombe R A randomised crossover trial to compare the potential of stannous fluoride and essential oil mouth rinses to induce tooth and tongue staining. Clin Oral Investig. 2012; 16:821-826
Tredwin CJ, Scully C, Bagan-Sebastian JV Drug-induced disorders of teeth. J Dent Res. 2005; 84:596-602
Addy M, Roerts WR Comparison of the bisguanide antiseptics alexidine and chlorhexidine. J Clin Periodontol. 1981; 8:220-230
Bagis B, Baltacioglu E, Özcan M, Ustaomer S Evaluation of chlorhexidine gluconate mouthrinse-induced staining using a digital colorimeter: an in vivo study. Quintessence Int. 2011; 42:213-223
Addy M, Mahdavi SA, Loyn T Dietary staining in vitro by mouth rinses as a comparative measure of antiseptic activity and predictor of staining in vivo. J Dent. 1995; 23:95-99
Claydon N, Hunter L, Moran J A 6-month home usage trail of 0.1% and 0.2% delmopinol mouthwashes. Effects on plaque, gingivitis, supragingival calculus and tooth staining. J Clin Periodontol. 1996; 23:220-228
Addy M, Moran JM The formation of stain on acrylic surfaces by the interaction of cationic antiseptic mouth rinses and tea. J Biomed Mater Res. 1984; 18:631-641
Carpenter GH, Pramanik R, Proctor GB An in vitro model of chlorhexidine-induced tooth staining. J Periodontal Res. 2005; 40:225-230
Zanatta FB, Antoniazzi RP, Rösing CK Staining and calculus formation after 0.12% chlorhexidine rinses in plaque-free and plaque covered surfaces: a randomized trial. J Appl Oral Sci. 2010; 18:515-521
Ayaslioglu E, Erkek E, Oba AA, Cebecioğlu E Doxycycline-induced staining of permanent adult dentition. Aust Dent J. 2005; 50:273-275
Garcia-López M, Martinez-Blanco M, Martinez-Mir I, Palop V Amoxycillin-clavulanic acid-related tooth discoloration in children. Pediatrics. 2001; 108
Matson KL, Miller SE Tooth discoloration after treatment with linezolid. Pharmacotherapy. 2003; 23:682-685
Kumaraguru T, Flanagam SE, Greeley SA Tooth discoloration in patients with neonatal diabetes after transfer on to glibenclamide. Diabetes Care. 2009; 32:1428-1430
Sánchez AR, Rogers RS, Sheridan PJ Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity. Int J Dermatol. 2004; 43:709-715
Mello H The mechanism of tetracycline staining in primary and permanent teeth. J Dent Child. 1967; 34:478-487
Jordan RE, Boksman L Conservative vital bleaching treatment of discolored dentition. Comp Cont Educ Dent. 1984; 5:803-808
Volovitz B, Shkap R, Amir J, Calderon S, Varsano I, Nussinovitch M Absence of tooth staining with doxycycline treatment in young children. Clin Pediatr (Phila). 2007; 46:121-126
Good ML, Hussey DL Minocycline: stain devil?. Br J Dermatol. 2003; 149:237-239
Pearson NL Nothing to smile about: drug-induced tooth discoloration. CPJ/RPC. 2007; 140:263-265
Alvarez JA, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL Dental fluorosis: exposure, prevention and management. Med Oral Patol Oral Cir Bucal. 2009; 14:E103-E107
Den Besten PK Mechanism and timing of fluoride effects on developing enamel. J Public Health Dent. 1999; 59:247-251
Pendrys DG, Katz RV, Morse DE Risk factors for enamel fluorosis in a nonfluoridated population. Am J Epidemiol. 1996; 143:808-815
Levy SM An update on fluorides and fluorosis. J Can Dent Assoc. 2003; 69:286-291
Lumbiganon P, Pengsaa K, Sookpranee T Ciprofloxacin in neonates and its possible adverse effect on the teeth. Pediatr Infect Dis J. 1991; 10:619-620
Auluck A, Thomas MS, Kundabala M, Sumanth KN Chlorodontia: minocycline induced staining of permanent dentition – a case report. J Conserv Dent. 2007; 10:89-92
McKenna BE, Lamey PJ, Kennedy JG, Bateson J Minocycline-induced staining of the adult permanent dentition: a review of the literature and report of a case. Dent Update. 1999; 26:160-162
Krastl G, Allgayer N, Lenherr P, Filippi A, Taneja P, Weiger R Tooth discoloration induced by endodontic materials: a literature review. Dent Traumatol. 2012; 29:2-7 https://doi.org/10.1111/j.1600-9657.2012.01141.x
Ahmed HM, Abbott PV Discolouration potential of endodontic procedures and materials: a review. Int Endod J. 2012; 45:883-897 https://doi.org/10.1111/j.1365-2591.2012.02071.x
Kim ST, Abbott P The effects of Ledermix paste as an intracanal medicament on the discolouration of teeth. Aust Endod J. 2000; 26:86-87
Kim JH, Kim Y, Shin SJ, Park JW, Jung IY Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. J Endod. 2010; 36:1086-1091
Tay FR, Mazzoni A, Pashley DH, Day TE, Ngoh EC, Breschi L Potential iatrogenic tetracycline staining of endodontically treated teeth via NaOCl/MTAD irrigation: a preliminary report. J Endod. 2006; 32:354-358
Krishnamurthy S, Sudhakaran S Evaluation and prevention of the precipitate formed on interaction between sodium hypochlorite and chlorhexidine. J Endod. 2010; 36:1154-1157
Hopcraft MS, Tan C Xerostomia: an update for clinicians. Aust Dent J. 2010; 55:238-244
Hellwig E, Lussi A Oral hygiene products and acidic medicines. Monogr Oral Sci. 2006; 20:112-118
Amaechi BT, Higham SM Dental erosion: possible approaches to prevention and control. J Dent. 2005; 33:243-252

Medication-related tooth discoloration: a review

From Volume 41, Issue 5, June 2014 | Pages 440-447

Authors

Manuel S Thomas

MDS

Associate Professor, Department of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Mangalore, Karnataka, India

Articles by Manuel S Thomas

Ceena Denny

BDS, MDS

Associate Professor, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Mangalore, India – 575001

Articles by Ceena Denny

Abstract

Tooth discoloration is a common problem for which patients seek dental care. Various medications can directly or indirectly result in tooth discoloration. As clinicians, it is our responsibility to know these therapeutic drugs which can cause tooth discoloration and educate our fellow colleagues to take necessary precautions when prescribing these medications. Therefore, the objective of this paper is to give an overview of the various medications that can be linked to tooth discoloration and to suggest the precautionary measures that can be taken to avoid or minimize it.

Clinical Relevance: Dental discoloration potential of medications always needs to be considered before prescribing them.

Article

Discoloration of the tooth is a common problem for which patients seek dental care. Alteration in the tooth colour can not only cause aesthetic displeasure in individuals, but can also be traumatizing psychologically. Tooth discoloration can be either extrinsic (where chromogens are present on the surface of the tooth) or intrinsic (where chromogens are present within the bulk of the tooth structure) or even internalized (where external stains are taken up into the tooth surface through enamel defects and porous surface of exposed dentine).1,2,3,4 Among the several causes for tooth discoloration, a variety of medications used systemically or locally have been implicated in tooth dyschromia (Table 1).5 In the aesthetically conscious world of today, tooth discoloration that is iatrogenic can be a liability. The purpose of this article is to throw some light on the drugs that can either directly or indirectly result in tooth discoloration and the precautions that need to be taken when prescribing or using these medications.

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