Hyaluronan and its Potential Role in Periodontal Healing

From Volume 29, Issue 3, April 2002 | Pages 144-148

Authors

Ryan Moseley

BSc, PhD

Lecturer in Oral Biochemistry, Department of Basic Dental Science, Dental School, University of Wales College of Medicine, Cardiff

Articles by Ryan Moseley

Rachel J. Waddington

BSc, PhD

Senior Lecturer in Oral Biochemistry, Department of Basic Dental Science, Dental School, University of Wales College of Medicine, Cardiff

Articles by Rachel J. Waddington

Graham Embery

BSc, PhD, DSc

Professor of Dental Science, Department of Clinical Dental Sciences, Edwards Building, School of Dentistry, University of Liverpool

Articles by Graham Embery

Abstract

Hyaluronan is a natural tissue component, which plays a vital role in the functioning of extracellular matrices, including those of the periodontium. This molecule is also important in relation to the mechanisms associated with inflammation and wound healing. The application of exogenous hyaluronan and hyaluronan-based biomaterials has been successful in manipulating and accelerating the wound healing process in a number of medical disciplines, as evident in ophthalmology, dermatology and rheumatology. It is conceivable that hyaluronan administration to periodontal sites could achieve comparable beneficial effects in periodontal healing and surgery, hence aiding treatment of periodontal disease.

Article